Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The collection presents a variety of promising new directions in Royce scholarship from an international group of scholars, including historical reinterpretations, explorations of Royce's ethics of loyalty and religious philosophy, and contemporary applications of his ideas in psychology, the problem of reference, neo-pragmatism, and literary aesthetics.

This is the review of the book by W.K.C. Guthrie, Filozofowie greccy od Talesa do Arystotelesa.

The Knower Paradox is an element of the class of paradoxes of self-reference. It demonstrates that any theory Ó which (1) extends Robinson arithmetic Q, (2) includes a unary knowledge predicate K, and (3) contains certain elementary epistemic principles involving K is inconsistent. In this paper I present different versions of the Knower Paradox (both in the framework of the first-order arithmetic and in the modal logic). There are several solutions of the paradox. Some of them I discuss in detail, (...) namely solution developed within modal logic, solution proposed by C. A. Anderson and solution proposed by P. Égré. The common defect of these proposals is that they developed a connection between the concepts of knowledge and provability. Finally, I suggest a solution using the basic ideas of the revision theory of definitions. (shrink)

Author: Siwiec Marek Kazimierz Title: ZBIGNIEW HERBERT – TOWARDS MYSTERY OF SOCRATES (Zbigniew Herbert – ku tajemnicy Sokratesa) Source: Filo-Sofija year: 2010, vol:.11, number: 2010/2, pages: 7-28 Keywords: MYSTERY OF SOCRATES, ZBIGNIEW HERBERT, JOURNEY TO THE GREEK ROOTS (BEGINNINGS) TO THE EUROPEAN CULTURE AND SOURCES OF THE EUROPEAN HUMANITY Discipline: PHILOSOPHY Language: POLISH Document type: ARTICLE Publication order reference (Primary author’s office address): E-mail: www:In the essay the author follows Zbigniew Herbert’s path by asking a question: (...) “What is a mystery of Socrates?”. The author wants to present that Zbigniew Herbert in his books took a journey, a spiritual wander, to the Greek roots (beginnings) to the European culture and sources of the European humanity. He distinguishes the difference between ‘root’ (or ‘beginning’) from ‘source’. “The portrait of Socrates” by Herbert reflects the two main dimensions of poet’s creative as well as philosophical aspirations. Socrates represents different reflections on the human condition. He encompasses various – for many philosophers – unpredictable dimensions of human existence. He has ability to rational, intellectual examination of the world as well as tendency to investigate his artistic poetic work and vocation. However, the mystery of Socrates appears to be a source of creative thinking. (shrink)

John Thackara emphasised that 80% of the negative impact on the natural environment has its origin in design and the randomness of its application. Considering the entirety of design practices, one would have a hard time disputing this. In contemporary times, design understood as design practices has assumed a servile role in relation to big corporations. One can observe the consequences of such practices in real time: social exclusion, the lack of design consideration or consideration of end users, the failure (...) of branding, and the polarisation of entire societies – these are only some dimensions of the current applications of design. Instead of the current applications, we need a change in the paradigm of both the theory of design and practical applications. Design needs a new code of application which would not only look good in social media, but would also be a clear point of reference in the design practice. (shrink)

This is the second book by Michael Heller which presents to English readers his previously written papers on science and theology. The first one, The New Physics and a New Theology is worth mentioning in this context because in it, Michael Heller proposes a new direction in theology - the theology of science. The theology of science as envisioned by Heller is defined as an authentic theological reflection on the existence, foundations, methods, and results of modern science. Its purpose is (...) to break down the mutual lack of trust between science and theology and to help theology advance to a new stage, where it can participate creatively in the currents of modern thought. Philosophers of science examine the boundaries of natural science and what can be known by the methods of science alone. Theology extends beyond these boundaries to include the supernatural, although Heller is far from embracing any kind of dualism. His way of extending these boundaries is different. A good example is provided by Einstein's famous question, „Why is the world comprehensible?" Neither Einstein nor any other philosopher or scientist is able to answer this question. It is theology that has to take over and seek the answer to Einstein's question. Heller provides more similar issues. (shrink)

In general introduction few examples of astronomical explanations of well-known and common local physical phenomena are presented. They are meant to show that it is often much easier to explain commonly experienced phenomena by investigating the behavior of something which is very far from the observer. In main chapters of the article the transparency of interstellar and intergalactic medium as well as the mystery of diffuse interstellar bands are presented. These very important fundamental problems are – for some reasons – (...) overlooked by contemporary researchers. Plausible mechanisms of sociological, psychological and methodological kinds are proposed in last chapter as a potential explanation of fading of the scientific attempts to understand the nature and to create better future for the mankind. These are ethics in science and interdisciplinary way of solving scientific problems. (shrink)

A specific shift has recently occured in the philosophy of science. This shift consists in stressing the importance of experiment in science. This enable one to find conclusive arguments in favor of „manipulative realism”. According to the author, a growing intrest in Bacon's thought is the source of the mentioned tendencies.

Jest to tłumaczenie Zarysów Pyrrońskich Sekstusa Empiryka. W pliku znajduje się początek wstępu oraz I sposób powściągnięcia sądu. This is a complete Polish translation of Sextus Empiricus' Outlines of Pyrrhonism. In the file you may find the beginning of the Preface and the translation of the I mode of suspension of judgment.

Jest to początek Zarysów Pyrrońskich Sekstusa Empiryka, ks. I (1-30) w nowym przekładzie. Całość tekstu ukaże się w Wydawnictwie UMK w połowie roku 2019. -/- This is the opening part of Sextus' Outlines of Pyrrhonism (I 1-30). The translation of the treatise will be published by Wydawnictwo UMK in the 2019.

This is the interview with Prof. Stefan Swieżawski, an eminent medievist and enthusiast of Thomas Aquinas' philosophy.

Jest to wybór z pracy Gadamera "Idea dobra..." Zawiera Przedmowę, Zakres problemu, Rozdział I (Sokratejska wiedza i niewiedza) oraz Posłowie tłumacza. This is the opening part of the Polish translation of Gadamers' The idea of the good... with the Translator's afterword.

Edmund Husserl, the founder of phenomenological philosophy, developed the concept of the so-called pure transcendental consciousness. The author of the article asks whether the concept of consciousness understood this way can constitute a model for AI consciousness. It should be remembered that transcendental consciousness is the result of the use of the phenomenological method, the essence of which is referring to experience (“back to things themselves”). Therefore, one can legitimately ask whether the consciousness that AI can achieve can possess the (...) characteristics attributed by Husserl to pure transcendental consciousness. The answer to such questions seems to be negative because AI, as created by humans, can only operate in the field of phenomena. Human intelligence, however, is capable of operating at the ontological level. In the face of difficulties in understanding the phenomenon of consciousness on a scientific basis, the question arises about the possibility of using the phenomenological concept of consciousness developed by Husserl as a starting point in analyzes aimed at answering the question about AI consciousness (The aim of the article is not to discuss in detail the contemporary state of research on consciousness. Therefore, many results currently achieved mainly in the field of neuroscience are omitted. It is just about indicating the possible application of Husserl’s transcendental concept of consciousness in research on AI consciousness). (shrink)

Zbigniew Tworak The early Leśniewski and the Liar AntinomyIn his early, prelogistic article „Critique of the Logical Principle of Excluded Middle” (1913) Stanislaw Leśniewski presents a certain solution to the Liar Antinomy. He argues that the Logical Principle of Excluded Middle is false but he defends the so-called Principle of Contradictory Sentences (the weaker version of the Logical Principle of Excluded Middle) and the Logical Principle of Contradiction. The paper discusses this solution. Leśniewski’s solution to the Liar antinomy differs (...) from Tarski’s in several important details. On the one hand, there is a connection between the proposition and a medieval solution to insolubilia, the so-called restrictio theory. A restrictio is a doctrine which has it that self-reference is illegitimate (either in all cases or in some cases only). On the other hand, there is a connection between the proposition and the contextual approach (what is communicated by the sentence varies with the context of use of the sentence). Keywords: Stanislaw Leśniewski, Liar Antinomy, restrictio theory. (shrink)

This paper explores some variants and aspects of multi-quantificational criteria of existence, examining these in the context of the debate between monism and pluralism in analytical philosophy. Assuming familiarity with the findings to date, we seek to apply to these the newly introduced concepts of “substitution” and “substitutional model”. Possible applications of formal theories involving multiple types of existential quantifier are highlighted, together with their methods of construction. These considerations then lead to a thesis asserting the irrelevance of both multi-quantificational (...) criteria and assumptions involving quantificational ontology to the debate between monism and pluralism in ontology. Many quantifiers cannot properly distinguish different modes of existence–as we aim to show by furnishing a general method for constructing counter-examples to any theory that assumes that different types of existential quantifier correspond to different modes of existence. (shrink)

Certain aspects of time physics were considered within the framework of quantum cosmology of the closed universe. Based on the general relativity we know that total energy of the closed universe is precisely equal to zero. This fact allows interpreting the creation of the closed universe as a spontaneous, causeless occurrence of respective quantum fluctuation, without any energy input. However, in such a universe the unitary evolution is “frozen”—no changes may occur, i.e. the universal cosmic time, which numbers the changes (...) in the state of the universe, cannot exist. This conclusion is obviously contrary to the experiment. For this reason the changes observed in the closed universe may be generated solely by non-unitary, irreversible and jumpwise evolution, associated with quantum measurement, which cannot be caused by any element of reality liable to linear laws of quantum theory. Therefore, quantum cosmology does not generate a closed thinking system. In consequence, this leads to an ontology called objective idealism. (shrink)

Gaston Bachelard (1884-1962) was a seminal figure in contemporary French philosophy. Together with Michel Foucault, Georges Canguilhem and Jean Cavailles, he shaped the 'French epistemological' school of philosophy of science. In France, Bachelard is a towering presence; in the English-speaking world, he is little known. Now, Zbigniew Kotowicz gives us the first English language, in-depth presentation of the entire spectrum of Bachelard's work: epistemology, poetic imagination and temporality. And he explores an old philosophical tradition that Bachelard's thought opens up (...) - atomism - a doctrine that has been almost forgotten and is much misunderstood ". (shrink)

The paper is devoted to the sophistic method of "two-fold arguments" (antilogic). The traditional understanding of antilogic understood as an expression of agonistic and eristic tendencies of the sophists has been in recent decades, under the influence of G.B. Kerferd, replaced by the understanding of antilogic as an independent argumentative technique, having its own sources, essence, and goals. Following the interpretation of G.B. Kerferd, according to which the foundation of the antilogic is the opposition of two logoi resulting from contradictions (...) or opposites, necessarily associated with the contradictory character of the sensual world, in the paper it is argued that the philosophical basis of antilogic should be sought in the presentation of the views attributed to Protagoras and "adherents of flux" in Plato's dialogue Theaetetus. (shrink)

This is a reprint of the chapter “Prelude: Antitrinitarianism in Poland before Socinus” by Zbigniew Ogonowski in his "Socinianism: History, Views, Legacy" (Rome: Edizioni di Storia e Letteratura, 2021), 3–56. Reprinted with the permission of Edizioni di Storia e Letteratura. We are grateful to Valentina Saraceni for her permission to reprint this material in the present volume. The paper takes an in-depth look at an early, pre-Socinian stage of Polish antitrinitarianism. First, it outlines the historical reasons for the emergence (...) of antitrinitarianism in Poland. Second, it explains how the early Polish antitrinitarians were able to develop a view substantial enough to provide a basis for Socinianism, a philosophical and religious movement with a pan-European reach. Third, it discusses similarities and differences between the two stages of Polish "Arianism", pre-Socinian and Socinian. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:LettersZbigniew Szawarski and Jacek A. PiatkiewiczPolish Code of Medical EthicsMadam:In the December 1992 issue of the Kennedy Institute of Ethics Journal you published the Polish Code of Medical Ethics with introductions by Jacek A. Piatkiewicz and Robert Baker. Jacek Piatkiewicz writes (p. 362), and Robert Baker follows him, that the new code "was approved by an overwhelming majority (449 for, 75 against, 58 abstaining)." I am afraid that these (...) figures are inconsistent with the data supplied by the Polish mass media. The leading Polish newspaper, Gazeta Wyborcza (16 December 1991), states that 354 delegates voted for the new code and 317 against it. The same figures are quoted by the most authoritative Polish political weekly, Polityka (4 January 1992).Mr. Piatkiewicz does not mention either that 40 delegates left the convention before the vote in protest over the undemocratic proceedings. If we add those 40 potentially negative votes to the 317 votes against, then the result is not at all "an overwhelming approval" for the new code.I am not a physician myself, and I was not present at the Second National Congress of Physicians in Bielsko-Biala, however, I find this discrepancy disturbing. Respect for facts seems to me equally imperative as respect for human life.Jacek A. Piatkiewicz Replies:In his letter Mr. Szawarski denies the data I presented on the vote approving the Polish Code of Medical Ethics. He has quoted the figures published by the Polish mass media as the true ones. Interestingly enough, he did not try to confirm them with the Polish General Medical Chamber, which has the original documents on the Extraordinary Second National Congress of Physicians. The figures I cited regarding the Code's approval are clearly stated on page 63 of the Congress proceedings.So where do the figures presented in Mr. Szawarski's letter come from? As Mr. Szawarski states, these figures have been published in some Polish newspapers, among them "the most authoritative Polish political weekly, Polityka" (a description that was especially accurate during the Communist period of Poland's history). The figures are simply untrue. The figures presented refer only to the result of the vote on article 37 of the Code, which concerns abortion. The very narrow margin (354 for, 317 against, 38 abstaining) decided the formulation of the exceptions to the abortion ban, which are "saving the mother's life and health" and "when pregnancy is the result of a criminal act." But what was the alternative considered in the vote? It was the single exception, "to save the mother's life," that was in the [End Page 355] original draft of the Code (page 44 of the Congress proceedings).Mr. Szawarski finds the discrepancy in the figures cited disturbing. I am disturbed too, but the cause of my concern is of a completely different nature. Why does Mr. Szawarski not try to reconcile "the discrepancy" by asking organizers of the Congress for an explanation?Zbigniew SzawarskiCentre for Philosophy and Health Care University of Swansea, WalesJacek A. PiatkiewiczGeneral Medical Council of PolandCopyright © 1993 The Johns Hopkins University Press... (shrink)